Dual-chamber syringe filling line (dual-chamber PFS)

A container designed for safe reconstitution

Dual-chamber PFS syringes incorporate two separate chambers divided by a plunger or barrier. They are available in glass or COP/COC, with typical volumes ranging from 0.5 to 2.0 mL. This format enables immediate reconstitution of a lyophilized product with its diluent just before injection.

They are sterile and suitable for drugs requiring fast and reliable preparation. This container stands out for several key advantages:

• Safe and controlled mixing at the patient’s bedside
• Reduced risk of contamination
• Simplified clinical handling

On the other hand, their design is more complex, and their manufacturing cost is higher. However, their added value largely outweighs these constraints for critical injectable products.

Practical applications and use cases

Dual-chamber syringes are widely used in high-safety pharmaceutical sectors. They are particularly suited to injectable therapies requiring immediate reconstitution, such as sensitive lyophilized products. Their use is common in hospitals, biotechnology settings, and specialized units administering high-value treatments.

They target indications where dosage precision and product integrity are essential. These syringes also support the logistical requirements of cold-chain processes thanks to their robust design and reliable closure interface.

A suitable filling line: EREA Pharma expertise

The performance of a dual-chamber syringe filling line (Dual-Chamber PFS) relies on its ability to handle the complexity of the container. EREA Pharma’s solutions address these challenges through full control of sequential filling, plunger positioning, and in-process control.

These lines include dedicated stations for precise dosing of both chambers, while ensuring gentle handling to avoid disturbing the lyophilized cake. They accommodate different materials, from glass to COP/COC, and provide strong stability in aseptic operations. Their advanced automation ensures consistent quality and smooth integration into regulated environments.

Thanks to their specific architecture and flexibility, Dual-Chamber PFS offer an optimal response to the challenges of reconstituted injectable products. EREA Pharma’s filling lines make it possible to fully leverage their potential. If you wish to evaluate a filling solution tailored to your requirements, a detailed study can be carried out to guide your project with precision.